Revolutionary research: Discovered new drugs for cancer and viruses
Revolutionary research: Discovered new drugs for cancer and viruses
researchers from the universities of Constance, Zurich and California have discovered a promising mechanism that could help to significantly improve the treatment of diseases such as cancer and viral diseases. In a recent study that was published in the journal molecular cell shown.
The focus of research is the N-MyristoylTransferasen (NMTS), special enzymes that play a key role in the modified production of proteins. A malfunction of these enzymes can lead to the development of diseases. The research team has now found that NMTS can be controlled in a targeted manner, which opens up new options for the development of medication. These could not only appear more effective, but also gentler, so that unwanted side effects could be limited. The approach, which proves to be a control center in the cell, offers great hope for millions of patients.The mechanism of the NMTS
The study shows in detail how NMTS are activated during protein production. They change the chemical structure of proteins by attaching myristic acid, which is decisive for their correct function. A newly discovered molecular process in which the "Nascent Polypeptide-Associated Complex" (NAC) plays a central role, coordinates the activity of the NMTS on the ribosome, the production facility of the proteins. This precise control could mean that medication in the future can be even more targeted at certain areas of the cell, which could outdo the previous therapies.
The research group led by Prof. Elke Deuerling shows that the knowledge about NMTS can serve as a springboard to develop new treatment approaches for diseases in which these enzymes play a crucial role. Funding by positions such as the German Research Foundation (DFG) and the European Research Council underlines the relevance of this work.
effects on clinical research
Developments in basic research also have an immediate impact on clinical studies. When participating in such studies, there are a variety of incoming and exclusion criteria that often affect gender, age and the state of health of the participants. Randomized controlled studies (RCT) that are considered the gold standard in research show effective ways to validate new medication. They are crucial to demonstrate the effectiveness, tolerance and security of new therapies.
With the focus on precise medication that causes fewer side effects, the new approaches could help many patients in the future to achieve a better quality of life. It is possible to benefit from a revolutionary type of treatment that is less invasive in the near future and can avert cancer death in many cases. Let's be excited to see how these exciting developments will continue to develop in the coming time.
There is a good wind in the research air, and the efforts of the scientists in Constance, Zurich and California could be the key to combating cancer and virus infections. A great example of internationally cooperating research that not only sharpens the profile of institutions, but can also have noticeable and positive effects on society.
| Details | |
|---|---|
| Ort | Konstanz, Deutschland |
| Quellen | |